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Compounded GLP-1 injections use the same active ingredients, are prepared by licensed pharmacies, and start as low as $129/month through telehealth providers

Primary Handling Editors: Liam Messin and Sonia Muliyil, in collaboration with the Nature Medicine team

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Direct and Metabolite Effects: While direct GLP-1R expression on -cells is low, degradation products of GLP-1, such as GLP-1(9-36) , may also inhibit glucagon secretion by activating inhibitory G proteins (Gi/o) and modulating calcium channels (Zheng et al., 2024)

Structure determination To prepare high-quality human GIPRG s complexes, the receptors C-terminal forty-five amino acids (Q422-C466) were truncated, and the NanoBiT tethering strategy was applied 25,37,38,53