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The National Institute for Health and Care Excellence (NICE) recognises semaglutide's role in diabetes management, particularly for patients requiring additional glycaemic control or those who would benefit from weight reduction

However, the metabolic and appetite changes can be significant and should be anticipated and managed appropriately

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some autoinjectors require waiting for a second click) Withdraw the needle as instructed and release the skin fold if used Do not rub the injection site afterwards Dispose of the needle immediately in a sharps binnever reuse needles

doi: 10.1007/s00018-010-0396-5 28 MeierJJ
