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References 1 SempleRKSavageDBCochranEKGordenPORahillyS

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PLoS One 6 , e97868 (2014)

One of the most frequently discussed side effects of this rapid weight loss is a noticeable depletion of facial fat, often leaving patients feeling as though their face has aged prematurely

After reviewing all available data on NAION with semaglutide, PRAC has recommended that the product information for semaglutide medicines is updated to include NAION as a side effect with a frequency of very rare (it may affect up to 1 in 10,000 people)

Managing injection site reactions Several practical strategies can minimize injection site issues