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[DOI] [PMC free article] [PubMed] [Google Scholar] 95.Chou CC, et al

Refrigeration rules before first use Before you use a GLP1 pen for the first time, it must be stored in a refrigerator between 36F and 46F (2C to 8C)

doi: 10.3389/fimmu.2025.1652796 Received 24 June 2025 Accepted 25 September 2025 Published 15 October 2025 Volume 16 - 2025 Edited by Ana Raquel Santiago, University of Coimbra, Portugal Reviewed by Mara Dominguez-Mozo, Health Research Institute of the Hospital Clnico San Carlos (IdISSC), Spain Ramtin Naderian, Semnan University of Medical Sciences, Iran Updates Copyright 2025 Ren, Niu, Wang, Guo, Hao, Gao, Liu and Wang

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The activated mTORC1 pathway then reciprocally enhances Glu metabolism [47], creating a positive feedback loop that sustains Gem-R