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Determining whether this conceptual advantage translates into clinical benefit will require prospective trials specifically designed to assess cognitive and neurodegenerative outcomes

Modern societies have moved from famine to feast and obesity and its co-morbidities now sweep the world as a global epidemic

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Personalized nutrition plans are particularly valuable as they consider individual dietary preferences, health goals, and potential metabolic responses to GLP-1 medications

Liraglutide and semaglutide are long-acting human GLP-1 analogues with high receptor affinity and sustained receptor occupancy, whereas dulaglutide is a larger fusion molecule conjugated to an IgG4 Fc fragment, resulting in distinct pharmacokinetics and tissue distribution

More recently, the FLOW study, which focused on evaluating the nephroprotective and cardioprotective efficacy of semaglutide, a GLP-1RA, in patients with T2DM and CKD (N = 3534), was stopped prematurely as it met certain pre-specified efficacy criteria, with a very high likelihood of study success on reducing the progression of renal disease [61]