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Following PSM, both groups consisted of 6,055 patients with well-balanced baseline characteristics (all SMD 0.05), and an E-value of 1.9 suggested robust findings against potential unmeasured confounders
The mechanisms enabling CNS access for GLP-1 analogues are not fully understood, but several routes have been proposed [72]
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Death by any cause was 13% lower among patients treated with GLP-1 receptor agonists
In addition to the anti-hyperglycemic effects, recent studies have exhibited anti-inflammatory effects of GLP-1RAs
