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Cooking your vegetables makes a difference, too

Kardie Tobb, DO, MS, FASPC, FACC, a boardcertified preventive cardiologist and the medical director for the Cone Health HeartCare Women's Heart Health and Cardio-Obstetrics Clinic, explains some of the most common reasons why GLP-1s may not deliver the results you're hoping for, including: You need a higher dose and have not yet reached a therapeutic dose as determined by your doctor High intake of liquid calories , including alcohol and ultra-processed foods Not getting enough protein , which can leave you persistently hungry and makes it harder to feel full Advanced diabetes or insulin resistance Taking other medications such as sulfonylureas, which lower blood sugar but can lead to weight gain Not adhering to your dosing schedule , such as inconsistent weekly injections or missed doses Differences in gut hormones or genetics And just because your GLP-1 isn't working immediately doesn't mean it won't work for you

Semaglutide reduces hunger signals in the brain and slows down how fast the stomach empties

It is ideal for those planning future body contouring or seeking comprehensive care from a single provider

The trials show the same thing: people carrying extra weight and living with heart failure did not just shrink on these drugs, they felt better and walked farther (Kosiborod, New England Journal of Medicine, 2023)