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Patient reports and clinical observations suggest that some individuals do experience muscle cramps while taking GLP-1 medications, though establishing direct causation remains challenging

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For instance, when initiating GLP-1 therapy, a gradual reduction in insulin doses can help prevent diabetic ketoacidosis

To ensure patient safety and minimize potential gastrointestinal side effects like nausea or bloating, Semaglutide is always introduced at a low starting dose, typically 0.25 mg

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Collectively, these data support a direct effect of GLP-1 on GLP-1 receptors within the heart