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For colorectal cancer, reductions in circulating insulin and systemic inflammation are plausible mechanisms, although further tissue-level validation is needed (Figure 5)

These medications suppress the production of inflammatory markers like IL-6, IL-1, TNF-, and CRP that damage blood vessels 9

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Of course, any time rapid weight loss is a side effect of a drug, interest (and demand) tend to spikeas does speculation about long-term risk factors and supply issues for patients treating chronic disease