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Cardiovascular outcomes trials (SUSTAIN-6, SELECT) demonstrate that long-term use reduces heart attack and stroke risk in people with obesity and existing heart disease

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24 Nevertheless, in most species, the majority of L cells are located in the distal gut, and the quantitative contributions of proximal gut L cells to the control of glucose homeostasis and circulating levels of GLP-1 throughout the day remains questionable

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Recreational drug use, particularly the use of methamphetamines, can cause severe dry mouth commonly referred to as meth mouth. Marijuana use can also provoke symptoms when smoked or vaped
