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Over the past 70 years, numerous synthetic approaches have been patented and reported
Research has shown that propionic and butyric acids can inhibit dendritic cell maturation, reduce the recognition of matrix metalloproteinases, suppress pro-inflammatory cytokines, and interact with T cells, thus protecting the intestinal mucosal barrier [92]
doi:10.1126/science.aah5143
Furthermore, mutations in the juxtamembrane domain led to tumorigenesis in an in vitro trial (Tavian et al., 2000)
doi: 10.1155/2016/2585230
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