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By staying hydrated, you can: help your body metabolize the semaglutide so its as effective as possible help your kidneys filter waste and byproducts of the medication from your blood maintain your energy and prevent dehydration help prevent or ease constipation or digestive distress Side effects of semaglutide weight loss drugs Studies have shown that most people taking semaglutide drugs have mild-to-moderate side effects, mostly around gastrointestinal upset or nausea (see: Mayo Clinic and Nature)