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The lack of VO2max improvement despite weight loss is concerning for endurance athletes whose performance depends heavily on cardiorespiratory fitness

In contrast, GLP1/GIP therapy was unable to consistently reduce body weight, food intake, or fat mass in PWA mice over the study period (Fig

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Appetite hormones shift, satiety signals change, energy expenditure adapts, cravings can intensify, and the brains reward pathways do what they were designed to do: push you back toward your prior weight

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The high cost of GLP-1 RAs may create a system where effective obesity treatment is available only to those with adequate insurance coverage or financial resources