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While peripherally administered GLP-1 seemingly crosses the blood brain barrier (BBB) via simple diffusion, the half-life of GLP-1 is less than 2 min, leading to disagreement regarding whether peripherally derived GLP-1 is what activates CNS GLP-1R under physiological conditions

Different role of intracellular loops of glucagon-like peptide-1 receptor in G-protein coupling

Morton JI, Marquina C, Shaw JE, Liew D, Polkinghorne KR, Ademi Z, et al

Shortage of diabetes, weight-loss drug Ozempic expected in Canada, says manufacturer THE CURRENT Canadians are taking Ozempic, but stigma around weight stops them talking about it GLP-1 drugs like Wegovy slow the passage of food through the stomach, helping people feel fuller longer

Zepbound patients were not aware that taking this GLP-1 for weight loss and diabetes could cause them to lose their vision

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