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Retatrutide's glucagon receptor agonism already stimulates lipolysis and increases energy expenditure

Inga Murawski for the generation of the BioRender figures in this manuscript Funding This work was supported by the Canadian Institutes for Health Research Project Grants 168836 and 162273)

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Additionally, case reports and prospective cohort studies of patients treated with GLP-1 RAs have demonstrated reductions in the Psoriasis Area and Severity Index (PASI) score, Physicians Global Assessment (PGA), and Dermatology Life Quality Index (DLQI) after 212 months of treatment [11,12,13,14,15,16]

Instead, prescriptions increased, research firm IQVIA found in an October 2025 report

It typically starts at the lowest dosage, which is gradually increased as the patient adjusts to the medication and tolerates its potential side effects