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Major randomized controlled trials did not document suicidal ideation as a primary safety signal, though such serious events may be underdetected in structured trials

The GLP-1 injections offered through online programs are typically compounded medications, prepared by licensed US pharmacies and available by prescription only

So, by aiding one problem (excess body fat or hyperglycaemia), GLP-1RAs could be inadvertently causing another problem (low muscle mass or frailty)

Still requires caution with certain surgeries and procedures

A dual GLP-1 and Gcg receptor agonist rescues spatial memory and synaptic plasticity in APP/PS1 transgenic mice

Tellingly, for the first time in 40 years obesity rates declined last year in the US