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Research has shown that semaglutide can lead to long-term weight loss in people with obesity

Ozempic is the most potent of all the GLP-1 medications, she said

Tirzepatide is administered via subcutaneous injection once weekly, which improves convenience and compliance compared to daily medications

Patient factors also shape the decision: insurance coverage (many plans require prior authorization or weight thresholds), metabolic health status, comorbidities, and whether the patient meets clinical criteria

It is prescription-only, offered after clinical assessment, and is distinct from Rybelsus, a lower-dose oral semaglutide licensed for type 2 diabetes

The Obesity Society, a scientific organization, warns people not to use compounded GLP-1s, because they may not contain the appropriate active ingredients