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Cyclodextrin complexes Cyclodextrins are cyclic oligosaccharides that form inclusion complexes with hydrophobic compounds like curcumin, enhancing its water solubility (Figure 8)

Red flag symptoms requiring urgent medical attention include: Signs of dehydration: excessive thirst, dark urine, dizziness, decreased urination, or confusion Severe abdominal pain, especially if localized to the right upper quadrant or accompanied by fever Blood in stool or black, tarry stools Persistent vomiting preventing adequate fluid intake Symptoms of pancreatitis: severe upper abdominal pain radiating to the back, nausea, and vomiting Rapid heart rate, weakness, or fainting Severe abdominal distension or inability to pass gas or stool (possible signs of intestinal obstruction) Seek emergency care (call 911 or go to the emergency department) for severe dehydration with confusion, fainting, or severe, unrelenting abdominal pain

Garrido-Santos for her valuable assistance in the preparation of Figure 1, which greatly enriched the quality of this review

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However, people are paying to use it off-label, contributing to shortages as the interest in the drug has spiked on social media

Dual GIP and GLP-1 receptor agonist tirzepatide alleviates hepatic steatosis and modulates gut microbiota and bile acid metabolism in diabetic mice