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(2025) 7:e70103

Clinical trials establishing the efficacy of these medications, including the STEP trials for semaglutide and the SURMOUNT trials for tirzepatide, all paired pharmacotherapy with structured lifestyle interventions, such as dietary counseling and physical activity targets

Abbreviations BMI, Body mass index

Some patients benefit from periodic biomarker testingmeasuring fasting glucose, insulin levels, and lipid panelsto detect early metabolic shifts before weight regain becomes apparent

This success is influencing broader industry trends

Certain fermented foods containing probiotics, such as kefir, sauerkraut, kimchi, and live yoghurt, may indirectly influence GLP-1 production by promoting a healthy gut microbiome