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Among the patients who develop NASH, 1020% will progress to higher-grade fibrosis and approximately 5% will develop overt cirrhosis (1) ( Figure 1 Triglycerides (TG) accumulation is likely one of the first steps in the pathophysiology of NAFLD as a result of an impaired free fatty acid (FFA) metabolism in the liver (Figure 2)

A recent study showed a serotonin 1B receptor circuit (5-HTR 1B AgRP paraventricular nucleus circuit) for appetite suppression in mice, which suggested that 5-HTR 1B is a potential new target in 5-HT-based weight-loss therapies

It is estimated that, by 2022, approximately 31% of adults worldwide failed to meet the minimum recommended levels of physical activitya figure that has increased since 2000 due to rising urbanization and mechanization [31]

The injection, named Ozempic, is FDA-approved to reduce blood sugar levels in adults with type 2 diabetes

Platforms like Wellavy make it easy to connect everything in one place - sleep, workouts, nutrition, medications, blood work

Polymer-Based Particulate Delivery System In recent years, there has been a surge in utilizing natural and synthetic biodegradable polymers to formulate micro- and nano-particle systems for targeted drug delivery