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[DOI] [PMC free article] [PubMed] [Google Scholar] 93.Wang L., Cheng C.K., Yi M., Lui K.O., Huang Y

Semaglutide does not directly cause primary headaches

May indicate measurement issues or other factors affecting response
These innovative treatments simultaneously target GLP-1, GIP, and glucagon pathwaysa significant advancement over current single or dual-hormone therapies
24 GLP-1 receptor agonists and other adverse effects Gastrointestinal adverse effects Nausea, vomiting, and diarrhea are the most commonly shown side effects of GLP-1 agonists

The private market was shaken in September 2025 when Eli Lilly implemented a UK-wide list price increase of up to 170% for privately purchased Mounjaro, a move that coincided with broader US administration pressure on pharmaceutical companies to raise prices in international markets
