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Heavier, high-fat, or very spicy meals may be harder to tolerate during this period

In all of these cases, the appropriate response is medical evaluation rather than discontinuing tirzepatide, which is unlikely to be the cause and is probably helping through its metabolic benefits

In one study published in Molecular Nutrition and Food Research, nicotinamide supplementation protected mice against diet-induced obesity, increased energy expenditure, and induced the beiging of white adipose tissue, a process that converts energy-storing fat cells into energy-burning cells

Retatrutide cardiovascular data is limited to early-phase trials

Future research will focus on the benefit of tirzepatide in patients with chronic kidney disease and non-alcoholic fatty liver disease
