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Tirzepatide is a prescription medication approved by the FDA for the treatment of type 2 diabetes mellitus (marketed as Mounjaro) and chronic weight management in adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with at least one weight-related comorbidity (marketed as Zepbound)

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Someone with favorable variants in the GLP1R gene may achieve 20% weight loss, while a person with less-responsive variants might achieve 1215% loss on the same dose