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(2025) 7:e70103
Interim commissioning guidance: implementation of NICE TA1026 (tirzepatide for weight management)
Some target hydration
Compelling evidence indicates that the cardiovascular benefits of GLP-1 receptor agonists (GLP-1RAs) extend beyond their anti-obesity and antidiabetic effects, involving direct cardiac mechanisms of action 2,18,42
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The difference is almost entirely attributable to water and glycogen depletion rather than true fat loss
