is tiredness a side effect of semaglutide Effects Week by Week: Pharmacist's Timeline semaglutide does it make you

(Ahmed Abdelmaksoud) and M.S.F

The results were highly encouraging, as Semaglutide continued to demonstrate its efficacy as a weight loss aid across a wider population

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The analysis included eight randomized controlled trials with 2,372 participants (all with BMI 27 kg/m) and found that weight regain was proportional to the amount initially lost.48 On average, participants who had taken liraglutide regained 2.2 kg, while those who had taken semaglutide or tirzepatide regained 9.69 kg after stopping the medication.48 Similarly, a 2025 review in Biomolecules showed that patients treated with GLP-1 or dual GLP-1/GIP agonists experience substantial weight loss (ranging from about 6% to over 20%) but also significant weight regain upon drug discontinuation

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