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La corta vida media del GLP-1 nativo y la ingeniera bioqumica propiciaron el desarrollo de agonistas del receptor de GLP-1 (AgGLP-1)

Baskin HJ, Cobin RH, Duick DS, Gharib H, Guttler RB, Kaplan MM, et al

GLP-1 receptor agonists like semaglutide are peptides that undergo some degree of hepatic and renal clearance

Published Phase 2 clinical data, reported in the New England Journal of Medicine, demonstrated substantial reductions in body weight over a 48-week treatment period across multiple dosing cohorts

10.1016/j.drup.2022.100821 [DOI] [PubMed] [Google Scholar] Cheng A

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