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Retatrutide adds a third arm glucagon receptor agonism which preclinical and Phase 2 data suggest contributes additional hepatic lipid mobilization and energy expenditure effects not observed with mono- or dual-agonist compounds
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This follows results from the STEP 2 and STEP 8 extension studies, where the 7.2 mg dose demonstrated superior weight loss and better weight maintenance compared to the currently approved 2.4 mg dose
The FDA states it is GRAS (generally recognized as safe)
