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Most clinical trials employed gradual dose titration protocols specifically to minimize gastrointestinal side effects, with discontinuation rates due to GI adverse events ranging from 47% in the STEP trials

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doi: 10.1111/j.1365-2125.2007.02890.x 74 IdornTKnopFKJorgensenMBJensenTResuliMHansenPMet al

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