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Clinical Effectiveness and Outcomes Weight Loss Efficacy SURMOUNT trials show significant long-term body-weight reductions: SURMOUNT-1 22.9% average weight reduction at 15 mg 94% reduced risk of progression to type 2 diabetes 99% remained diabetes-free NNT = 9[7][8] SURMOUNT-3 6.9% initial lifestyle-based loss + 21.1% additional with tirzepatide Total mean loss 26.6% Placebo regained 3.3%[7] SURMOUNT-4 20.9% loss during lead-in +5.5% with continuation vs +14.0% regain on placebo 89.5% maintained 80% of initial loss Total loss 25.3% vs 9.9% placebo[8] Comparative Efficacy Tirzepatide produces greater mean weight reduction than semaglutide in comparative trials[6]

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Novo Nordisks diabetes medication Ozempic cut the risk of patients developing advanced kidney disease or dying from kidney or heart complications, adding to the evidence the drug has broad health benefits.