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Just as is the case with any other injection, there may be a few side effects associated with GLP-1 injections

In the STEP-1 trial (68 weeks), adults on semaglutide lost a mean of 14.9% of body weight versus 2.4% on placebo

Pancreatitis has been reported rarely, at approximately 0.3% of patients in trials

Based on current phase 3 TRIUMPH trial timelines, a regulatory submission to the MHRA is not anticipated before 20262027 at the earliest, with a possible marketing authorisation in 20272028 and NHS availability potentially from 2028 onwards, subject to NICE appraisal

If youve had side effects but theyve improved and you want to try a higher dose, this could improve your results

Moreover, serious adverse events and severe hypoglycaemia rates were comparable regardless of whether an SGLT2i was used, with P -heterogeneity values of 0.29 and 0.50, respectively