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This effect is consistent with what has been observed with other GLP-1 based compounds and is thought to reflect a combination of weight-mediated reduction in vascular resistance and direct vascular effects of GLP-1 receptor activation

The mechanisms underlying Semaglutides anti-obesity effects are multifaceted and include appetite suppression, reduced energy intake, delayed gastric emptying, and increased energy expenditure

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NHS use will follow the usual process, including an evaluation by NICE, and theres no NICE recommendation for oral semaglutide for weight management at this stage

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