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A 2020 report in the Journal of the Endocrine Society indicated that dulaglutide (Trulicity) may cause small bowel obstruction
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However, Ozempic and similar GLP-1 receptor agonists have been linked to severe gastrointestinal issues, including gastroparesis, or stomach paralysis
There is no evidence of a physical withdrawal syndrome associated with tirzepatide discontinuation, meaning patients do not experience acute symptoms similar to those seen with certain other medications
A first CRL typically adds six to twelve months to the approval timeline
