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Two published human studies demonstrate efficacy of intravenous and subcutaneous exendin 9-39 in preventing hypoglycemia by reducing postload insulin secretion (29, 65)

[DOI] [PubMed] [Google Scholar] [3].Basit A, Fawwad A, Qureshi H, et al

Pharmacologic Overview of GLP-1 Receptor Agonists Mechanism of Action Endogenous GLP-1 is an incretin hormone secreted by intestinal L-cells postprandially

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Delayed gastric emptying, gastroparesis-like symptoms, intestinal obstruction, biliary disease, and pancreatic safety concerns were variably reported, with heterogeneous and sometimes conflicting evidence across studies