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Tirzepatide overcame this issue, being effective in subjects with obesity independently of the length of the history of obesity, and this was surprising. Muscogiuri said more studies are needed to see whether the similarities in weight loss for adults with different obesity durations are maintained over a long-term period.

Its not FDA approved, but its often the only way to get this medication affordably without insurance, especially through telehealth clinics

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Mounjaro is intended for adults with type 2 diabetes and may be prescribed off-label for weight loss in people with obesity

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Zepbound is used for long-term weight management in adults with obesity (with a body mass index of 30 or higher) and overweight (with a body mass index of 27 or higher) with at least one weight-related condition, such as high blood pressure, type 2 diabetes, or high cholesterol