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Epub 2023 Mar 2

Blood sugar increase: HbA1c rises, often returning toward pre-treatment levels

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These changes increase arrhythmic susceptibility, particularly atrial fibrillation, and accelerate the progression of heart failure [1619]
A conclusion in favor of the non-inferiority of Januvia to glipizide may be limited to patients with baseline A1C comparable to those included in the study (over 70% of patients had baseline A1C less than 8% and over 90% had A1C less than 9%)

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