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The experimental data indicate GLP-1 and its analogs to have direct effects on the cardiovascular system, in addition to their classic glucoregulatory actions

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Following the predefined inclusion and exclusion criteria, 36 studies were included in this systematic review and underwent qualitative analysis

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But human observational evidence is increasingly reassuring on major malformations when confounding is handled carefullyfor example, large datasets show no substantial increased risk of major congenital malformations with early exposure, and a European teratology cohort reported no increase in major birth defects vs diabetes/high-BMI comparators