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Among the GLP-1 RAs and a dual GLP-1/GIP RA, exenatide has the most developed pharmacokinetic model (9 of 30),61,177184 followed by semaglutide (8 of 30),68,162,182,185189 liraglutide and dulaglutide (each 5 of 30),156,177,182,189194 and tirzepatide (3 of 30).58,73,195 The developed pharmacokinetic models were used either solely to predict pharmacokinetics (18 of 30) or integrated with pharmacodynamic models to evaluate responses (12 of 30)

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"Medi-Cal Rx Contract Drugs List (CDL) Update: GLP-1 Agonist Coverage Changes Effective January 1, 2026." Wegovy, Zepbound, and Saxenda removed from CDL for weight loss