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MariTide is the first obesity treatment with monthly or less frequent dosing to demonstrate such robust efficacy in a Phase II study

A separate strategy involves co-packaging -cells with GLP-1-loaded NPs within alginate hydrogels, which significantly improved cellular metabolism and resulted in an 8-fold increase in insulin secretion [130]

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Duration of intervention was 12, 26, 40 and 52 weeks in one, one, three and two studies, respectively

In true, limited clinical use cases, they may be used when a patient has a legitimate medical reason that prevents them from taking an FDA-approved product, such as an allergy to an inactive ingredient

Acknowledgements We thank Milena Braga-Basaria, MD (Voxmed Medical Communications) for critically reviewing and suggesting improvements to the manuscript