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Deng J, Gu S, Shao H, Dong H, Zou D, Shi L

Managing dose escalation burping Each dose increase essentially restarts the GI adaptation process

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7 As the first approved dual agonist targeting both GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptors, tirzepatide demonstrated weight loss exceeding 20% in its pivotal trials, establishing a new therapeutic ceiling