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Medicare will cover Wegovy (semaglutide), Foundayo (orforglipron), and the KwikPen formulation of Zepbound (tirzepatide)

They mention the silence

In patients with type 2 diabetes, semaglutide is reported to improve glycaemic control dose-dependently, decreasing HbA 1c levels by 1.7% (18.7 mmol/mol) vs 0.5% (5.5 mmol/mol) with placebo and 4.8 kg of weight loss vs 1.2 kg with placebo, relative to baseline

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The integration of kinase (PKA, CDK5, GSK3) and small G-protein (IQGAP1) signalling pathways through CaMKK2, all of which have demonstrated links with human bipolar disorder, points to the possibility that bipolar disorder is a signalopathy that stems from defects in this signal transduction network, and potentially explains the clinical heterogeneity and polygenic nature of the condition