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Voltage-dependent K+ channels in pancreatic cells: role, regulation and potential as therapeutic targets

Aims: This is a comprehensive review summarising the role of glucagon-like peptide-1 (GLP-1) receptor agonists and glucagon/glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 receptor dual or triple agonists in the treatment of metabolic dysfunction-associated steatohepatitis (MASH)

Rotate among sites with every weekly dose and clean the site with alcohol before each injection

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Tier 2: Growth Hormone Secretagogues

Early data are promising: retatrutide, a leading candidate in this class, produced 24.2% average weight loss at 48 weeks in a Phase 2 trial, exceeding results seen with current medications