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Giannopoulos, Alexandrov, and Siasos contributed to critical revision of the article for important intellectual content

And here is a detail that gets overlooked constantly: participants who received an initial starting dose of 4 mg experienced more GI symptoms than those who started at 2 mg

Although a single RCT failed to observe a statistically significant improvement in HOMA-IR (85), this discrepancy is more likely attributable to limited sample sizes, restricted follow-up windows, and heterogeneity in baseline metabolic phenotypes rather than a lack of efficacy

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but, if the Wegovy based semaglutide revenue projections are any indication, it could certainly be 17% or higher within a few short years of product launch