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1,2 A serious allergic reaction to a GLP-1 medication If youve previously had a severe allergic reaction to tirzepatide, semaglutide, liraglutide, or any other GLP-1 medication, you shouldnt be re-prescribed one

These findings were inconsistent with those of previous studies, which reported a strong association between GLP-1 RAs and various types of cancers

Supplementary Video 1 (download MP4 3D reconstruction of DVC GLP1R neurons following injection of Glp1r-ires-Cre mouse with a Cre-dependent AAV expressing a soma-restricted fluorophore

However, these benefits may never come to fruition if GLP-1 RAs induce dietary modifications that create maladaptive gut microbiome shifts, especially over the long term

[171] A 2025 observational study reported a modest increased risk of a serious eye condition in people with diabetes taking glucagon-like peptide-1 (GLP-1) receptor agonists