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Going below 1,500 calories risks excessive muscle loss, metabolic adaptation, and nutrient deficiencies that slow long-term progress

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Key supplements for anyone on GLP-1 therapy include a high-quality multivitamin, vitamin B12 (especially important since some compounded formulations include B12 for this reason), vitamin D, and a fiber supplement if constipation is an issue

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Despite these limitations, this early analysis provides timely insight into who is receiving oral semaglutide for obesity immediately following approval and demonstrates the value of real-world data for monitoring new drug uptake in near real time

For patients seeking dual-compound therapy, GLP-Squared injection begins at $249 monthly