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Consequently, GLP-1 that is secreted by intestinal L-cells is rapidly degraded by dipeptylpeptidase-4 (DPP-4) in the endothelium of the portal circulation and in the liver, as well as by a soluble circulating moiety of DPP-4

Medicare is already spending billions on drugs like Ozempic, and Biden recently proposed expanding access to obesity treatments.

Circanas research expects that GLP-1 adoption will grow as the prices of the medicines continue to fall for both the diabetes- and the weightloss-focused medications

India Issues Urgent GLP-1 Drug Safety Alert The Indian Pharmacopoeia Commission (IPC) has issued a public notice on 14 May calling on doctors, patients, and consumers to closely monitor and report any adverse reactions linked to semaglutide and other GLP-1 receptor agonists including dulaglutide, liraglutide, and tirzepatide