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Description
Semaglutide, the active ingredient in Ozempic, is one of the most potent GLP-1 receptor agonists and may be a first-line option, especially in people with heart disease or obesity

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Adding retatrutide 5 to 10 BPM on top of that pushes the total increase into a range where healthy individuals might notice uncomfortable cardiovascular symptoms

From glucose lowering agents to disease/diabetes modifying drugs: a SIMPLE approach for the treatment of type 2 diabetes

Sebag-Montefiore, D

It is the active ingredient in Novo Nordisk's Wegovy (weight management indication) and Ozempic (diabetes indication)