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Managing Side Effects During and After Clearance Some patients experience what feels like medication hangover effects in the days after their last dosemild nausea, reduced appetite, or fatigue may linger even as the compound clears

PMID 30683512

Timing, Dosing, and Lifestyle Strategies That Minimize Nausea Injecting semaglutide at night, 30 minutes before bed, allows nausea to peak while you're asleep rather than during work or family activities

Generally, however, the results are significant

No, mild constipation alone is rarely a reason to stop treatment

Some of the most significant clinical research on GLP-1 receptor agonists in recent years has examined their relationship to cardiovascular outcomes