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In conclusion, tirzepatide exhibited greater effects on markers of insulin sensitivity and beta-cell function compared to dulaglutide

Its immune-modulating properties have attracted considerable interest among clinicians seeking supportive therapies for individuals with recurrent infections or impaired immune function

Tirzepatide as monotherapy improved markers of beta-cell function and insulin sensitivity in type 2 diabetes (SURPASS-1)

The treatment began with a 2.5 mg weekly dose of tirzepatide, gradually increasing to the maintenance doses of 10 mg or 15 mg

Due to the above-mentioned effects of TZD on glycemic, hepatic metabolism, and inflammation, treatment with dual-agonism may reduce or reverse liver damage (lobular inflammation, hepatic steatosis, liver cell damage, and fibrosis) and metabolic dysfunction ( GLP-1RA has multiple hepatic effects on MAFLD, involving an adaptation of portal and plasma glucagon and insulin concentrations, hepatic insulin sensitivity and improving hepatocyte mitochondrial function ( There is a randomized controlled phase 2 study with the objective to explore the use of TZP as a treatment for MAFLD, providing strong evidence [NCT04166773]

The research teams behind these studies found that tirzepatide was consistently linked with improvements in glycemic control and weight loss