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Tirzepatide, a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 receptor agonist (GLP-1 RA), has shown superior efficacy in glycemic control, weight loss and cardiometabolic outcomes compared to GLP-1 agonists alone

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This is primarily due to cost and duration

But the way they influence appetite thats where many people see such dramatic results. However, with rising demand and high costs, many are exploring whether smaller, microdosed amounts can deliver benefits without the intense side effects often associated with standard dosing

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However, it is recognized that vagal terminals activated within the GI tract send signals up to the brain