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In addition, a non-competitive ECD-binding antibody, Fab fragment (Fab7F38) 17 , was added along with the TMD-binding negative allosteric modulator (NAM) PF-06372222 (originally designed for GCGR) 18 for co-crystallization and successful determination of the structure to 3.2 resolution (Fig

E.et al (2017)

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On one hand, IR leads to abnormal glucose uptake and oxidation, reduced glycogen synthesis, and decreased ability to inhibit lipid metabolism, resulting in glucose metabolism imbalance